Email: shijie@bjmu.edu.cn
医学博士，教授，博士生导师，国家杰出青年基金获得者，教育部长江学者特聘教授，北京大学中国药物依赖性研究所常务副所长，药物依赖性研究北京市重点实验室主任，中国毒理学会药物依赖性专业委员会主任委员，国家禁毒委中国毒品滥用防治专家委员会副主任委员兼秘书长，《中国药物依赖性杂志》主编，中国睡眠研究会副理事长，海峡两岸医药卫生交流协会睡眠医学专业委员会副主任委员兼秘书长，中国毒理学会常务理事，中国药物滥用防治协会常务理事，中国心理学会生理心理学分会理事，中国神经科学学会精神病学基础与临床分会委员，中国医师协会睡眠医学专业委员会精神心理学组副组长，中华医学会精神医学分会物质依赖学组副组长，长期从事药物成瘾及相关疾病的神经机制和干预策略研究，在Science、JAMA Psychiatry、Am J Psychiatry、Mol Psychiatry、Biol Psychiatry、eLife及J Neurosci等SCI期刊发表论文160余篇，作为负责人主持国家自然科学基金、科技部、脑科学与类脑研究北方科学中心以及世界卫生组织等30余项科研项目，多次获得教育部优秀成果自然科学奖一等奖、中华医学科技奖一等奖和二等奖、吴阶平-保罗·杨森医学药学奖等学术奖励。
主要研究方向
1）成瘾的神经和遗传影像学机制及干预
2）睡眠-觉醒的脑功能调控及其机制研究
3）抑郁症的神经机制及干预
代表性论著
1. Sun Y#, Chang S#, Liu Z, Zhang L, Wang F, Yue W, Sun H, Ni Z, Chang X, Zhang Y, Chen Y, Liu J, Lu L, Shi J*. Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence. Mol Psychiatry. 2021, 26(4):1152-1161.
2. Han Y#, Sun CY#, Meng SQ#, Tabarak S, Yuan K, Cao L, Yan W, Xu LZ, Deng JH, Zhu WL, Li JL, Lu L*, Xue YX*, Shi J*. Systemic immunization with altered myelin basic protein peptide produces sustained antidepressant-like effects. Mol Psychiatry. 2020, 25(6):1260-1274.
3. Ma J, Bao YP*, Wang RJ, Su MF, Liu MX, Li JQ, Degenhardt L, Farrell M, Blow FC, Ilgen M, Shi J*, Lu L*. Effects of medication-assisted treatment on mortality among opioids users: a systematic review and meta-analysis. Mol Psychiatry. 2019, 24(12):1868-1883.
4. Sun Y#, Chang S#, Wang F, Sun H, Ni Z, Yue W, Zhou H, Gelernter J, Malison RT, Kalayasiri R, Wu P, Lu L*, Shi J*. Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison. Transl Psychiatry. 2019, 9(1):249.
5. Ai SZ#, Yin YL#, Chen Y, Wang C, Sun Y, Tang XD, Zhu LS*, Shi J*. Promoting subjective preferences in simple economic choices during nap. eLife. 2018, 7: e40583.
6. Xue YX#, Deng JH#, Chen YY, Zhang LB, Wu P, Huang GD, Luo YX, Bao YP, Wang YM, Shaham Y, Shi J, Lu L*.Effect of Selective Inhibition of Reactivated Nicotine-Associated Memories With Propranolol on Nicotine Craving. JAMA Psychiatry. 2017, 74(3):224-232.
7. Chen J, Liang J, Lin X, Zhang Y, Zhang Y, Lin L, Shi J*. Sleep deprivation promotes habitual control over goal-directed control: behavioral and neuroimaging evidence. J Neurosci. 2017, 37(49):11979-11992.
8. Liang J#, Li JL#, Han Y#, Luo YX, Xue YX, Zhang Y, Zhang Y, Zhang LB, Chen ML, Lu L, Shi J*. Calpain-GRIP Signaling in Nucleus Accumbens Core Mediates the Reconsolidation of Drug Reward Memory. J Neurosci. 2017, 37(37):8938-8951
9. Zhang Y#, Xue Y#, Meng S, Luo Y, Liang J, Li J, Ai S, Sun C, Shen H, Zhu W, Wu P, Lu L, Shi J*. Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug Relapse. Biol Psychiatry. 2016, 79(11): 928-39.
10. Sun Y, Zhao LY, Wang GB, Yue WH, He Y, Shu N, Lin QX, Wang F, Li JL, Chen N, Kosten TR, Feng JJ, Tan YL, Han HB, Lu L, Shi J*. ZNF804A variants confer risk for heroin addiction by modulating neurocognitive and neuroanatomical phenotypes. Addict Biol. 2016, 21(3): 657-66.
11. Luo YX#, Xue YX#, Liu JF, Shi HS, Jian M, Han Y, Zhu WL, Bao YP, Wu P, Ding ZB, Shen HW, Shi J, Shaham Y, Lu L*. A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking. Nat Commun. 2015, 6:7675.
12. Jian M#, Luo YX#, Xue YX, Han Y, Shi HS, Liu JF, Yan W, Wu P, Meng SQ, Deng JH, Shen HW, Shi J*, Lu L*. eIF2α dephosphorylation in basolateral amygdala mediates reconsolidation of drug memory. J Neurosci. 2014, 34(30):10010-10021.
13. Suo L＃, Zhao L＃, Si J, Liu J, Zhu W, Chai B, Zhang Y, Feng J, Ding Z, Luo Y, Shi H, Shi J*, Lu L*. Predictable chronic mild stress in adolescence increases resilience in adulthood. Neuropsychopharmacology. 2013, 38(8):1387-400.
14. Xue YX#, Luo YX#, Wu P, Shi HS, Xue LF, Chen C, Zhu WL, Ding ZB, Bao YP, Shi J, Epstein DH, Shaham Y, Lu L*. A memory retrieval-extinction procedure to prevent drug craving and relapse. Science. 2012, 336(6078):241-245.
15. Zhang XL, Shi J*, Zhao LY, Sun LL, Wang J, Wang GB, Epstein DH, Lu L. Effects of stress on decision-making deficits in formerly heroin-dependent patients after different durations of abstinence. Am J Psychiatry. 2011, 168(6):610-616.