薛言学  副研究员

电话：01082802470-520

Email：yanxuexue@bjmu.edu.cn

简介

北京大学中国药物依赖性研究所副研究员，中组部万人计划青年拔尖人才，国家自然科学学基金委优秀青年基金获得者，北京大学博雅青年学者，北京大学中国药物依赖性研究所重点室副主任。主要从事情绪及相关精神障碍的发病机制研究，发表SCI期刊发表论文40余篇，总引用1500余次，其中以第一作者或者通讯作者在Science、JAMA Psychiatry、Molecular Psychiatry、Nature Communications、Biological Psychiatry、Neuropsychopharmacology、The Journal of Neuroscience等SCI期刊发表论文14篇，单篇最高引用360余次，研究发现相继被Science、JAMA Psychiatry等杂志专评，认为其研究发现为成瘾治疗提供了新途径，是向物质成瘾治疗迈出的标志性一步。任中国神经科学会应激神经生物学分会委员，中国毒理学会药物依赖性专业委员会青年委员。研究先后得到国家自然科学基金，973项目青年科学家专题、北京市自然科学基金等资助。                                                                                                                                                                      主要研究兴趣和方向

1.异常记忆（如成瘾记忆和创伤性记忆）的存储、去稳定化及消除的细胞及环路机制

2.社会行为（如共情、帮助等）的神经生物学基础

代表性论著

1.       Huang X, Chen YY , Shen Y , Cao X, Li A , Liu Q , Li Z , Zhang LB ,Dai W , Tan T , O Arias-Carrion*, Xue YX*, Su H* and Yuan TF* . Methamphetamine abuse impairs motor cortical plasticity and Function. Mol Psychiatry. 2017, 22(9):1274-1281. IF: 13.204

2.       Xue YX,Chen YY, Zhang LB, Zhang LQ, Huang GD, Sun SC, Deng JH, Luo YX, Bao YP, Wu P, Han Y, Hope BT, Shaham Y, Shi J, Lu L. Selective inhibition of amygdala neuronal ensembles encoding nicotine-associated memories inhibits nicotine preference and relapse. Biol Psychiatry. 2017 [Epub ahead of print]. IF: 11.412

3.       Xue YX^#, Deng JH^#, Chen YY, Zhang LB, Wu P, Huang GD, Luo YX, Bao YP, Wang YM, Shaham Y, Shi J, Lu L. Effect of selective inhibition of reactivated nicotine-associated memories with propranolol on nicotine craving. JAMA Psychiatry. 2017, 74(3):224-232.IF: 15.307

4.       Zhang Y^#, Xue Y^#, Meng S, Luo Y, Liang J, Li J, Ai S, Sun C, Shen H, Zhu W, Wu P, Lu L, Shi J. Inhibition of lactate transport erases drug memory and prevents drug relapse. Biol Psychiatry. 2016, 79(11):928-39. IF: 11.412

5.       Zhu ZZ^#, Xue YX^#, Han HB, Liu JF, Meng SQ, Chen C, Yang JL, Wu P, Lu L. Overexpression of Protein Kinase Mζ in the Prelimbic Cortex Enhances the Formation of Long-Term Fear Memory. Neuropsychopharmacology. 2015, 40(10):2487. IF: 6.403

6.       Luo YX^#, Xue YX^#, Liu JF, Shi HS, Jian M, Han Y, Zhu WL, Bao YP, Wu P, Ding ZB, Shen HW, Shi J, Shaham Y, Lu L.A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking. Nat Commun. 2015, 6:7675.  IF: 11.329

7.       Liu J, Zhao L, Xue Y, Shi J, Suo L, Luo Y, Chai B, Yang C, Fang Q, Zhang Y, Bao Y, Pickens CL, Lu L. An unconditioned stimulus retrieval extinction procedure to prevent the return of fear memory. Biol Psychiatry. 2014, 76(11):895-901. IF: 10.255

8.       Xue YX^#, Xue LF^#, Liu JF, He J, Deng JH, Sun SC, Han HB, Luo YX, Xu LZ, Wu P, Lu L. Depletion of perineuronal nets in the amygdala to enhance the erasure of drug memories. J Neurosci. 2014 May 7;34(19):6647-58. IF: 6.344

9.       Ren ZY^#, Liu MM^#, Xue YX^#, Ding ZB, Xue LF, Zhai SD, Lu L.A critical role for protein degradation in the nucleus accumbens core in cocaine reward memory. Neuropsychopharmacology. 2013, 38(5):778-90.  IF: 7.833

10.    Xue YX^#, Luo YX^#, Wu P^#, Shi HS, Xue LF, Chen C, Zhu WL, Ding ZB, Bao YP, Shi J, Epstein DH, Shaham Y, Lu L.A memory retrieval-extinction procedure to prevent drug craving and relapse. Science. 2012, 336(6078):241-5. IF: 31.02