翟海峰，药学博士（日本）,助理研究员

专业：药理学

研究兴趣：

　　精神活性物质与神经精神可塑性

　　成瘾性药物与药物依赖性

　　阿片成瘾、复吸机理中的神经营养因子信号通路

　　阿片复吸的动物模型及防复吸药物研发

教育经历：

　　2002.4-2005.3 日本德岛文理大学　药学部，药学博士

　　1994.8-1997.8 中国人民解放军军事医学科学院，理学硕士（药理学）

　　1988.8-1992.7 北京中医学院(现，北京中医药大学)　中药学系，理学学士

　　1985.8-1988.7 河北省隆化县存瑞中学（高中）

工作经历：

　　1992.8-1994.7 河北省药物研究所（石家庄），研究实习员

　　1997.8-2002.8 中国人民解放军事医学科学院微生物流行病研究所，助理研究员

最近发表文章 :

1. Haifeng Zhai, Kousuke Nakade, Masataka Oda, Yasuhide Mitsumoto, Jun Sakurai, Yoshiyasu Fukuyama. Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2). European Journal of Pharmacology 2005; 516 (2): 112-117

2.H. Zhai, T. Inoue, M. Moriyama, T. Esumi, Y. Mitsumoto, Y. Fukuyama. Neuroprotective Effects of 2, 5-Diaryl-3, 4-dimethyltetrahydrofuran Neolignans Biological & pharmaceutical Bulletin 2005; 28(2): 289-293.

3.Zhai H, Nakatsukasa M, Mitsumoto Y, Fukuyama Y. Neurotrophic effects of talaumidin, a neolignan from Aristolochia arcuata, in primary cultured rat cortical neurons. Planta Medica 2004; 70(7):598-602.

4.Esumi T, Makado G, Zhai H, Shimizu Y, Mitsumoto Y, Fukuyama Y. Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan. Bioorganic & Medicinal Chemistry Letters 2004, 14(10): 2621-5.

5.Inoue M, Zhai H, Sakazaki H, Furuyama H, Fukuyama Y, Hirama M. TMC-95A, a reversible proteasome inhibitor, induces neurite outgrowth in PC12 cells. Bioorganic & Medicinal Chemistry Letters 2004, 14(3): 663-5.

6.Zhai H, Nakade K, Mitsumoto Y, Fukuyama Y. Honokiol and magnolol induce Ca2+ mobilization in rat cortical neurons and human neuroblastoma SH-SY5Y cells. European Journal of Pharmacology 2003, 474(2-3): 199-204.

7.Fukuyama Y, Nakade K, Minoshima Y, Yokoyama R, Zhai H, Mitsumoto Y. Neurotrophic activity of honokiol on the cultures of fetal rat cortical neurons. Bioorganic & Medicinal Chemistry Letters 2002, 12(8): 1163-6.

8.Haifeng Zhai, Kosuke Nakade, Yasuhide Mitsumoto, Yoshiyasu Fukuyama. Neurotrophic activities of honokiol and magnolol and their action mechanism. Yakugaku Zasshi (Journal of the pharmaceutical society of Japan) 2003, 123 (s3): 98-101

9.Massaaki Akagi, Toshimasa Tada, Akiko Shirono, Yoshiyasu Fukuyama, Kousuke Nakade, Haifeng Zhai, Yumiko Yasui, Reiko Akagi. Neuroprotective effect of magnolol in the hippocampus of senescence-accelerated mice (SAMP1). International Congress Series 2004, 1260: 405-408

国际会议以简报形式发表：

1.Pharmaceutical Sciences World Congress (PSWC2004) ---2nd World Congress of the Board of Pharmaceutical Sciences of FIP 2004, May 30- June 3 Kyoto Japan
(P3E-V-041) Talaumidin, a neurotrophic neolignan from Aristolochia arcuata Mater
Haifeng Zhai, Shouko Maeda, Mitsuko Ogata, Yusuhide Mitsumoto, Yoshiyasu Fukuyama

联系方式：

北京大学中国药物依赖性研究所
北京海淀区学院路38号 (100083)
Tel:(010)82802470-315
Fax:(010)62032624
Email: zhaihf@bjmu.edu.cn , zhaihaifeng@lycos.com